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KMID : 0620920080400010092
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Experimental & Molecular Medicine
2008 Volume.40 No. 1 p.92 ~ p.97
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Endothelin 1 protects HN33 cells from serum deprivationinduced neuronal apoptosis through Ca2+-PKCα-ERK pathway
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Park Moon-Ho
Lee Dae-Hie
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Abstract
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Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and ET-3) were added to HN33 (mouse hippocampal neuron × neuroblastoma) cells. Among the three types of ET, only ET-1 increased the intracellular calcium levels in a PLC dependent manner with the induction of ERK 1/2 activation. As the result of ET-1 exposure, the survival rate of HN33 cells and the PKCα translocation into the plasma membrane were increased. We suggest that ET-1 participated in the neuroprotective effect involving the calcium-PKCα-ERK1/2 pathway.
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KEYWORD
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calcium, cell survival, endothelins, mitogen-activated protein kinase 1, neurons, protein kinase C
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